PoplarV1, Main, Exploration, bibRecord, 000D05

Rates and predictors of relapse following discontinuation of antipsychotic medication after a first episode of psychosis.

Identifieur interne : 000D05 ( Main/Exploration ); précédent : 000D04; suivant : 000D06

Rates and predictors of relapse following discontinuation of antipsychotic medication after a first episode of psychosis.

Auteurs : Meghan Bowtell [Australie] ; Scott Eaton [Australie] ; Kristen Thien [Australie] ; Melissa Bardell-Williams [Australie] ; Linglee Downey [Australie] ; Aswin Ratheesh [Australie] ; Eoin Killackey [Australie] ; Patrick Mcgorry [Australie] ; Brian O'Donoghue [Australie]

Source :

Schizophrenia research [ 1573-2509 ] ; 2018.

RBID : pubmed:29066258

Descripteurs français

KwdFr :
- Abstention thérapeutique (statistiques et données numériques), Adolescent (MeSH), Enquêtes et questionnaires (MeSH), Femelle (MeSH), Humains (MeSH), Jeune adulte (MeSH), Modèles des risques proportionnels (MeSH), Mâle (MeSH), Neuroleptiques (effets indésirables), Récidive (MeSH), Troubles psychotiques (traitement médicamenteux), Troubles psychotiques (épidémiologie), Études rétrospectives (MeSH).
MESH :
- effets indésirables : Neuroleptiques.
- statistiques et données numériques : Abstention thérapeutique.
- traitement médicamenteux : Troubles psychotiques.
- épidémiologie : Troubles psychotiques.
- Adolescent, Enquêtes et questionnaires, Femelle, Humains, Jeune adulte, Modèles des risques proportionnels, Mâle, Récidive, Études rétrospectives.

English descriptors

KwdEn :
- Adolescent (MeSH), Antipsychotic Agents (adverse effects), Female (MeSH), Humans (MeSH), Male (MeSH), Outcome Assessment, Health Care (MeSH), Proportional Hazards Models (MeSH), Psychotic Disorders (drug therapy), Psychotic Disorders (epidemiology), Recurrence (MeSH), Retrospective Studies (MeSH), Surveys and Questionnaires (MeSH), Withholding Treatment (statistics & numerical data), Young Adult (MeSH).
MESH :
- chemical , adverse effects : Antipsychotic Agents.
- drug therapy : Psychotic Disorders.
- epidemiology : Psychotic Disorders.
- statistics & numerical data : Withholding Treatment.
- Adolescent, Female, Humans, Male, Outcome Assessment, Health Care, Proportional Hazards Models, Recurrence, Retrospective Studies, Surveys and Questionnaires, Young Adult.

Abstract

BACKGROUND

There is uncertainty about the required duration of long-term antipsychotic maintenance medication after a first episode of psychosis. Robust predictors of relapse after discontinuation are yet to be identified. The present study aimed to determine the proportion of young people who discontinue their antipsychotic medication after a first episode of psychosis, the proportion who experience relapse, and predictors of relapse.

METHODS

A retrospective study of all individuals presenting to the Early Psychosis Prevention and Intervention Centre between 01/01/11 and 31/12/13 was conducted. A Cox regression analysis was conducted to identify predictors of relapse.

RESULTS

A total of 544 young people with a FEP were included. A trial of discontinuation was undertaken by 61% of the cohort. Median duration of antipsychotic medication prior to first trial of discontinuation was 174.50days. Amongst those trialing discontinuation, 149 (45.8%) experienced relapse in a median follow-up time post discontinuation of 372days. On multivariate analysis, predictors of relapse were a diagnosis of cannabis abuse disorder (HR: 1.40), and longer duration of antipsychotic medication (HR: 1.05).

CONCLUSION

Antipsychotic discontinuation frequently occurs earlier than guidelines recommend. Individuals with a diagnosis of cannabis abuse are more likely to experience relapse and addressing this substance abuse prior to discontinuation could possibly reduce relapse rates.

DOI: 10.1016/j.schres.2017.10.030
PubMed: 29066258

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 001110
to stream Main, to step Curation: 001110

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en">Rates and predictors of relapse following discontinuation of antipsychotic medication after a first episode of psychosis.</title>
<author><name sortKey="Bowtell, Meghan" sort="Bowtell, Meghan" uniqKey="Bowtell M" first="Meghan" last="Bowtell">Meghan Bowtell</name>
<affiliation wicri:level="4"><nlm:affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road Parkville, Victoria 3052, Australia; Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Victoria 3052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
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<orgName type="university">Université de Melbourne</orgName>
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<region type="état">Victoria (État)</region>
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<author><name sortKey="Eaton, Scott" sort="Eaton, Scott" uniqKey="Eaton S" first="Scott" last="Eaton">Scott Eaton</name>
<affiliation wicri:level="4"><nlm:affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road Parkville, Victoria 3052, Australia; Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Victoria 3052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road Parkville, Victoria 3052, Australia; Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Victoria 3052</wicri:regionArea>
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<author><name sortKey="Thien, Kristen" sort="Thien, Kristen" uniqKey="Thien K" first="Kristen" last="Thien">Kristen Thien</name>
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<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
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<author><name sortKey="Downey, Linglee" sort="Downey, Linglee" uniqKey="Downey L" first="Linglee" last="Downey">Linglee Downey</name>
<affiliation wicri:level="4"><nlm:affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road Parkville, Victoria 3052, Australia; Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Victoria 3052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
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<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ratheesh, Aswin" sort="Ratheesh, Aswin" uniqKey="Ratheesh A" first="Aswin" last="Ratheesh">Aswin Ratheesh</name>
<affiliation wicri:level="4"><nlm:affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road Parkville, Victoria 3052, Australia; Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Victoria 3052, Australia; Orygen Youth Health, 35 Poplar Road, Parkville, Victoria 3052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road Parkville, Victoria 3052, Australia; Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Victoria 3052, Australia; Orygen Youth Health, 35 Poplar Road, Parkville, Victoria 3052</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Killackey, Eoin" sort="Killackey, Eoin" uniqKey="Killackey E" first="Eoin" last="Killackey">Eoin Killackey</name>
<affiliation wicri:level="4"><nlm:affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road Parkville, Victoria 3052, Australia; Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Victoria 3052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road Parkville, Victoria 3052, Australia; Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Victoria 3052</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcgorry, Patrick" sort="Mcgorry, Patrick" uniqKey="Mcgorry P" first="Patrick" last="Mcgorry">Patrick Mcgorry</name>
<affiliation wicri:level="4"><nlm:affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road Parkville, Victoria 3052, Australia; Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Victoria 3052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road Parkville, Victoria 3052, Australia; Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Victoria 3052</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="O Donoghue, Brian" sort="O Donoghue, Brian" uniqKey="O Donoghue B" first="Brian" last="O'Donoghue">Brian O'Donoghue</name>
<affiliation wicri:level="4"><nlm:affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road Parkville, Victoria 3052, Australia; Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Victoria 3052, Australia; Orygen Youth Health, 35 Poplar Road, Parkville, Victoria 3052, Australia. Electronic address: brian.odonoghue@orygen.org.au.</nlm:affiliation>
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<wicri:regionArea>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road Parkville, Victoria 3052, Australia; Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Victoria 3052, Australia; Orygen Youth Health, 35 Poplar Road, Parkville, Victoria 3052</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
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<series><title level="j">Schizophrenia research</title>
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<imprint><date when="2018" type="published">2018</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term>
<term>Antipsychotic Agents (adverse effects)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Outcome Assessment, Health Care (MeSH)</term>
<term>Proportional Hazards Models (MeSH)</term>
<term>Psychotic Disorders (drug therapy)</term>
<term>Psychotic Disorders (epidemiology)</term>
<term>Recurrence (MeSH)</term>
<term>Retrospective Studies (MeSH)</term>
<term>Surveys and Questionnaires (MeSH)</term>
<term>Withholding Treatment (statistics & numerical data)</term>
<term>Young Adult (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Abstention thérapeutique (statistiques et données numériques)</term>
<term>Adolescent (MeSH)</term>
<term>Enquêtes et questionnaires (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Jeune adulte (MeSH)</term>
<term>Modèles des risques proportionnels (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Neuroleptiques (effets indésirables)</term>
<term>Récidive (MeSH)</term>
<term>Troubles psychotiques (traitement médicamenteux)</term>
<term>Troubles psychotiques (épidémiologie)</term>
<term>Études rétrospectives (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antipsychotic Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Psychotic Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Neuroleptiques</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Psychotic Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Withholding Treatment</term>
</keywords>
<keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Abstention thérapeutique</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Troubles psychotiques</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Troubles psychotiques</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Outcome Assessment, Health Care</term>
<term>Proportional Hazards Models</term>
<term>Recurrence</term>
<term>Retrospective Studies</term>
<term>Surveys and Questionnaires</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Enquêtes et questionnaires</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Modèles des risques proportionnels</term>
<term>Mâle</term>
<term>Récidive</term>
<term>Études rétrospectives</term>
</keywords>
</textClass>
</profileDesc>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>There is uncertainty about the required duration of long-term antipsychotic maintenance medication after a first episode of psychosis. Robust predictors of relapse after discontinuation are yet to be identified. The present study aimed to determine the proportion of young people who discontinue their antipsychotic medication after a first episode of psychosis, the proportion who experience relapse, and predictors of relapse.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>A retrospective study of all individuals presenting to the Early Psychosis Prevention and Intervention Centre between 01/01/11 and 31/12/13 was conducted. A Cox regression analysis was conducted to identify predictors of relapse.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>A total of 544 young people with a FEP were included. A trial of discontinuation was undertaken by 61% of the cohort. Median duration of antipsychotic medication prior to first trial of discontinuation was 174.50days. Amongst those trialing discontinuation, 149 (45.8%) experienced relapse in a median follow-up time post discontinuation of 372days. On multivariate analysis, predictors of relapse were a diagnosis of cannabis abuse disorder (HR: 1.40), and longer duration of antipsychotic medication (HR: 1.05).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>Antipsychotic discontinuation frequently occurs earlier than guidelines recommend. Individuals with a diagnosis of cannabis abuse are more likely to experience relapse and addressing this substance abuse prior to discontinuation could possibly reduce relapse rates.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29066258</PMID>
<DateCompleted><Year>2018</Year>
<Month>11</Month>
<Day>26</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>12</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1573-2509</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>195</Volume>
<PubDate><Year>2018</Year>
<Month>05</Month>
</PubDate>
</JournalIssue>
<Title>Schizophrenia research</Title>
<ISOAbbreviation>Schizophr Res</ISOAbbreviation>
</Journal>
<ArticleTitle>Rates and predictors of relapse following discontinuation of antipsychotic medication after a first episode of psychosis.</ArticleTitle>
<Pagination><MedlinePgn>231-236</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0920-9964(17)30658-8</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.schres.2017.10.030</ELocationID>
<Abstract><AbstractText Label="BACKGROUND">There is uncertainty about the required duration of long-term antipsychotic maintenance medication after a first episode of psychosis. Robust predictors of relapse after discontinuation are yet to be identified. The present study aimed to determine the proportion of young people who discontinue their antipsychotic medication after a first episode of psychosis, the proportion who experience relapse, and predictors of relapse.</AbstractText>
<AbstractText Label="METHODS">A retrospective study of all individuals presenting to the Early Psychosis Prevention and Intervention Centre between 01/01/11 and 31/12/13 was conducted. A Cox regression analysis was conducted to identify predictors of relapse.</AbstractText>
<AbstractText Label="RESULTS">A total of 544 young people with a FEP were included. A trial of discontinuation was undertaken by 61% of the cohort. Median duration of antipsychotic medication prior to first trial of discontinuation was 174.50days. Amongst those trialing discontinuation, 149 (45.8%) experienced relapse in a median follow-up time post discontinuation of 372days. On multivariate analysis, predictors of relapse were a diagnosis of cannabis abuse disorder (HR: 1.40), and longer duration of antipsychotic medication (HR: 1.05).</AbstractText>
<AbstractText Label="CONCLUSION">Antipsychotic discontinuation frequently occurs earlier than guidelines recommend. Individuals with a diagnosis of cannabis abuse are more likely to experience relapse and addressing this substance abuse prior to discontinuation could possibly reduce relapse rates.</AbstractText>
<CopyrightInformation>Copyright © 2017 Elsevier B.V. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bowtell</LastName>
<ForeName>Meghan</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road Parkville, Victoria 3052, Australia; Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Victoria 3052, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Eaton</LastName>
<ForeName>Scott</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road Parkville, Victoria 3052, Australia; Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Victoria 3052, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thien</LastName>
<ForeName>Kristen</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road Parkville, Victoria 3052, Australia; Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Victoria 3052, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bardell-Williams</LastName>
<ForeName>Melissa</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road Parkville, Victoria 3052, Australia; Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Victoria 3052, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Downey</LastName>
<ForeName>Linglee</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road Parkville, Victoria 3052, Australia; Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Victoria 3052, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ratheesh</LastName>
<ForeName>Aswin</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road Parkville, Victoria 3052, Australia; Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Victoria 3052, Australia; Orygen Youth Health, 35 Poplar Road, Parkville, Victoria 3052, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Killackey</LastName>
<ForeName>Eoin</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road Parkville, Victoria 3052, Australia; Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Victoria 3052, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McGorry</LastName>
<ForeName>Patrick</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road Parkville, Victoria 3052, Australia; Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Victoria 3052, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>O'Donoghue</LastName>
<ForeName>Brian</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road Parkville, Victoria 3052, Australia; Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Victoria 3052, Australia; Orygen Youth Health, 35 Poplar Road, Parkville, Victoria 3052, Australia. Electronic address: brian.odonoghue@orygen.org.au.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>10</Month>
<Day>21</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>Schizophr Res</MedlineTA>
<NlmUniqueID>8804207</NlmUniqueID>
<ISSNLinking>0920-9964</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014150">Antipsychotic Agents</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014150" MajorTopicYN="N">Antipsychotic Agents</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017063" MajorTopicYN="N">Outcome Assessment, Health Care</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016016" MajorTopicYN="N">Proportional Hazards Models</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011618" MajorTopicYN="N">Psychotic Disorders</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012008" MajorTopicYN="N">Recurrence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011795" MajorTopicYN="N">Surveys and Questionnaires</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D028761" MajorTopicYN="N">Withholding Treatment</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Antipsychotic medication</Keyword>
<Keyword MajorTopicYN="Y">Discontinuation</Keyword>
<Keyword MajorTopicYN="Y">Psychosis</Keyword>
<Keyword MajorTopicYN="Y">Relapse</Keyword>
<Keyword MajorTopicYN="Y">Schizophrenia</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year>
<Month>07</Month>
<Day>24</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2017</Year>
<Month>09</Month>
<Day>19</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>10</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>10</Month>
<Day>27</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2018</Year>
<Month>11</Month>
<Day>27</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>10</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">29066258</ArticleId>
<ArticleId IdType="pii">S0920-9964(17)30658-8</ArticleId>
<ArticleId IdType="doi">10.1016/j.schres.2017.10.030</ArticleId>
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</pubmed>
<affiliations><list><country><li>Australie</li>
</country>
<region><li>Victoria (État)</li>
</region>
<settlement><li>Melbourne</li>
</settlement>
<orgName><li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Bowtell, Meghan" sort="Bowtell, Meghan" uniqKey="Bowtell M" first="Meghan" last="Bowtell">Meghan Bowtell</name>
</region>
<name sortKey="Bardell Williams, Melissa" sort="Bardell Williams, Melissa" uniqKey="Bardell Williams M" first="Melissa" last="Bardell-Williams">Melissa Bardell-Williams</name>
<name sortKey="Downey, Linglee" sort="Downey, Linglee" uniqKey="Downey L" first="Linglee" last="Downey">Linglee Downey</name>
<name sortKey="Eaton, Scott" sort="Eaton, Scott" uniqKey="Eaton S" first="Scott" last="Eaton">Scott Eaton</name>
<name sortKey="Killackey, Eoin" sort="Killackey, Eoin" uniqKey="Killackey E" first="Eoin" last="Killackey">Eoin Killackey</name>
<name sortKey="Mcgorry, Patrick" sort="Mcgorry, Patrick" uniqKey="Mcgorry P" first="Patrick" last="Mcgorry">Patrick Mcgorry</name>
<name sortKey="O Donoghue, Brian" sort="O Donoghue, Brian" uniqKey="O Donoghue B" first="Brian" last="O'Donoghue">Brian O'Donoghue</name>
<name sortKey="Ratheesh, Aswin" sort="Ratheesh, Aswin" uniqKey="Ratheesh A" first="Aswin" last="Ratheesh">Aswin Ratheesh</name>
<name sortKey="Thien, Kristen" sort="Thien, Kristen" uniqKey="Thien K" first="Kristen" last="Thien">Kristen Thien</name>
</country>
</tree>
</affiliations>
</record>

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Rates and predictors of relapse following discontinuation of antipsychotic medication after a first episode of psychosis.

Rates and predictors of relapse following discontinuation of antipsychotic medication after a first episode of psychosis.

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